Nano technological Approaches to Fight Infectious Diseases

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Nano technological Approaches to Fight Infectious Diseases
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Thu 26 March 2020
Thursday 26 March 2020
1:00 PM - 2:30 PM
Ended

IMSE Lunchtime Seminar Series

Challenges in Antimicrobial Resistance

The challenge that will be discussed in this session is:

Nano technological Approaches to Fight Infectious Diseases

Join us for this informal session where we will hear two presentations and then discuss a topic over lunch. Lunch is provided and free. The presentations and discussions will be lead by Dr Anna Kloechner and Dr Tiago Dias da Costa .

Biography

Dr Anna Kloeckner

Anna Klöckner studied biology and received her Ph.D. in 2016 from the University of Bonn. Her Ph.D. focused on the effect of antibiotics on the chlamydial life cycle. Since 2016 she holds a postdoctoral position at the German Center for Infection Research (DZIF) working in the group of Dr. Fabian Grein at the Institute of Pharmaceutical Microbiology (University of Bonn, Germany). She investigates the mode of action of antimicrobial substances using whole cell and biochemical screenings.

Dr Tiago Dias da Costa

Tiago Costa obtained his PhD in Molecular Biology from University of Umeå, Sweden in 2012 where he studied, the molecular and biochemical details of Yersinia Type III Secretion System (T3SS) translocators in the lab of Prof. Matthew Francis.

As a postdoctoral researcher in the laboratory of Prof. Gabriel Waksman (ISMB, London, UK) he studied the structural and molecular details of the E.coli conjugative Type IV Secretion System (T4SS) by cryo-electron microscopy (Cryo-EM) (Costa et al, Nat Rev Micro, 2015). He solved the structure of the iconic bacterial F-pilus at near-atomic resolution by cryo-EM, which provides the first atomic view of a bacterial extracellular appendage made of a protein-lipid complex. This study set the stage for understanding how DNA is transported from one bacterial cell (donor) to another (recipient), a process that leads to the spread of antibiotics resistance genes (Costa et al, Cell, 2016).

Recently, he solved the 3.3 Å-resolution cryo-EM structure of the T4SS core complex from Xanthomonas citri, a phytopathogen that utilizes this system to kill bacterial competitors (Sgro & Costa et al. Nat Micro, 2018).

Tiago Costa joined the Department of Life Sciences at Imperial College, London, UK in 2017 as a Lecturer in Bacterial Pathogenesis and Group Leader at the MRC Center for Molecular Bacteriology and Infection to study by Cryo-EM, the role of Bacterial Secretion Systems in pathogenicity. To fully understand how these macromolecular machines work, he uses a multi-disciplinary approach that includes: bacterial genetics (gene disruption and site-specific mutagenesis), membrane proteins biochemistry, cutting-edge single particle Cryo-EM, X-ray crystallography and protein cross-linking coupled with mass spectrometry (XL-MS).

How do I get there?

The easiest way to get to Roderic Hill Building (A2 on the campus map) from the Sherfield walkway.

The entrance to ACEX is adjacent to the Union shop (selling stationery and clothing) and directly opposite a doorway into the senior common room.

Walking with the common rooms on your left hand side, you will eventually reach the entrance to the ACE Extension on your right hand side.

Walk through the ACEX's glass doors main entrance, up the short flight of stairs and zig-zag through to the foyer of Chemical Engineering. Ahead you will see into the control room of the Chemical Engineerig pilot plant (a large pipework system visible beyond the control room).

Turn left, walking around-and-beyond the enclosed staircase, and into a long social area with seating under the windows. Head through towards the whole length of the breakout seating and go through the double doors at the end, into a corridor of offices.

Continue along the corridor through to the Department of Aeronautics.

Follow the corridor around to the right. At the end, go through the left-hand set of double doors that connect the ACEX to a stairwell of the Roderic Hill Building, marked level 2.

For rooms RODH 252, 253 and 254, head up two floors until you reach the fourth floor of the stairwell, which leads to the second floor of the Roderic Hill Building.

NB: The floor numbering is not clear - stairwell level 4 actually leads to RODH Building floor 2.

As you walk ahead through double doors into the corridor, the lecture theatres are on the right hand side, and each has two doorways.

More Events in the Challenge To Antimicrobial Resistance Series

Thursday 13 February Lunchtime Seminar - Challenges to Antimicrobial Stewardship presented by Dr Nina J. Zhu and Dr Esmita Charani

Thursday 20 February Lunchtime Seminar – Antimicrobial Resistance within Infectious and Heritable Diseases presented by Dr Julien Vaubourgeix and Yi Liu

Thursday 27 February Lunchtime Seminar - Healthcare Associated Infections and Antimicrobial Resistance presented by Dr Jon Otter and Dr Pau Herrero-Viñas

Wednesday 4 March Briefing Paper Launch - "Smart surfaces" to address infection and antimicrobial resistance
_

Thursday 19 March Lunchtime Seminar - Lymphatic System Transport and Vaccine Adjuvants presented by Professor James Moore and Dr Anna Blakney

Thursday 26 March Lunchtime Seminar - Nano technological Approaches to Fight Infectious Diseases presented by Dr Anna Kloechner and Dr Tiago Dias da Costa

If you have any questions about accessibility requirements please email Leah Adamson (IMSE Events Officer) on l.adamson@imperial.ac.uk

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